RAY, HPP star
Hypophosphatasia (hypo-fahs-fuh-TAY-shuh), or HPP, is a rare, inherited disease that affects the bones and other parts of the body.
People with HPP have a mutation in the ALPL gene, which may cause missing or not enough alkaline phosphatase (ALP) enzyme. This means that people with HPP have ALP levels lower than the healthy normal for their age and sex. When this is the case, the body has trouble making healthy bones. Low ALP levels can make bones soft, weak, and deformed, and cause other symptoms of HPP.
Learn more about ALP and how STRENSIQ® (asfotase alfa) works to replace it.
HPP looks different for every person. The condition can affect people of all ages and may vary in terms of severity of signs and symptoms—even in the same family. New symptoms can appear at any age. Symptoms can continue long-term, and they can worsen over time.
HPP can affect many different parts of the body. Early tooth loss, frequent bone injuries, and muscle weakness and pain are some examples of impact.
Use the skeletal graphic to explore more impacts of HPP.
Not an exhaustive list
Skull and brain
It is common for people of all ages with HPP to need some form of an assistive device to help them get around.
A person who shows signs and symptoms of HPP should talk to their doctor about taking a blood test to examine their ALP level. After a thorough exam and reviewing medical history, if blood test results reveal their ALP level is low for someone of their age and sex, a doctor may diagnose them with HPP. HPP is often misdiagnosed. ALP can be low because of HPP, but it can also be low for other reasons. Because HPP is rare, not every doctor has the same amount of experience with the disease. Also, some of the symptoms of HPP can be symptoms for other, more common conditions.
Signs and symptoms on physical
examination,
x-rays, or in patient history
Persistently low ALP enzyme levels*
Signs and symptoms on physical examination,
x-rays, or in patient history
Persistently low ALP enzyme levels*
Check with your doctor for the appropriate age- and sex-adjusted reference range.
After all those years, I finally
received my diagnosis,
and I felt
vindicated and surprisingly happy.
I knew there was a
treatment, and I was excited to try it.”
Sheila, HPP STAR
Below are other diseases that may be more common
and have shared symptoms with HPP.
Diseases in bold often have overlapping symptoms
and therefore can be common misdiagnoses.
When it comes to rare diseases, specialists are important. Specialists are trained to treat rare diseases and may better understand ways to manage symptoms.
If you believe you or someone you care for has HPP but has not been diagnosed, look for a specialist who may be familiar with HPP. Some specialists who may be able to help include:
Study the role that genes play in disease and health
Study the bones, joints, ligaments, tendons, and muscles
Study hormone imbalances
Study pain and disorders of the joints, muscles, tendons, bones, and other connective tissues
Enroll in OneSource™ to get personalized patient support from Alexion at 1.888.765.4747.
Learn More about OneSource™
AT ONESOURCE, WE ARE BY YOUR SIDE THROUGHOUT YOUR JOURNEY, FROM LEARNING ABOUT YOUR CONDITION TO HELPING YOU ACCESS THE THERAPY YOU'VE BEEN PRESCRIBED. PATIENTS' NEEDS ARE OUR TOP PRIORITY.
–Deana,
ONESOURCE CASE MANAGER
STRENSIQ may cause serious side effects, including
The most common side effects of STRENSIQ include local skin injection-site reactions (red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys.
STRENSIQ may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed.
These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1‑800‑FDA‑1088.
INDICATION
What is STRENSIQ?
STRENSIQ is a prescription medicine used to treat people with
perinatal/infantile- and
juvenile-onset hypophosphatasia (HPP).
STRENSIQ may cause serious side effects, including
The most common side effects of STRENSIQ include local skin injection-site reactions (red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys.
STRENSIQ may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed.
These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1‑800‑FDA‑1088.
INDICATION
What is STRENSIQ?
STRENSIQ is a prescription medicine used to treat people with
perinatal/infantile- and
juvenile-onset hypophosphatasia (HPP).
