RAY, HPP star
Hypophosphatasia (hypo-fahs-fuh-TAY-shuh), or HPP, is a rare, inherited disease that affects the bones and other parts of the body.
People with HPP have a mutation in the ALPL gene, which may cause missing or not enough alkaline phosphatase (ALP) enzyme. This means that people with HPP have ALP levels lower than the healthy normal for their age and sex. When this is the case, the body has trouble making healthy bones. Low ALP levels can make bones soft, weak, and deformed, and cause other symptoms of HPP.
Learn more about ALP and how STRENSIQ® (asfotase alfa) works to replace it.
HPP looks different for every person. The condition can affect people of all ages and may vary in terms of severity of signs and symptoms—even in the same family. New symptoms can appear at any age. Symptoms can continue long-term, and they can worsen over time.
HPP can affect many different parts of the body. Early tooth loss, frequent bone injuries, and muscle weakness and pain are some examples of impact.
Use the skeletal graphic to explore more impacts of HPP.
Not an exhaustive list
Skull and brain
It is common for people of all ages with HPP to need some form of an assistive device to help them get around.
A person who shows signs and symptoms of HPP should talk to their doctor about taking a blood test to examine their ALP level. After a thorough exam and reviewing medical history, if blood test results reveal their ALP level is low for someone of their age and sex, a doctor may diagnose them with HPP. HPP is often misdiagnosed. ALP can be low because of HPP, but it can also be low for other reasons. Because HPP is rare, not every doctor has the same amount of experience with the disease. Also, some of the symptoms of HPP can be symptoms for other, more common conditions.
Signs and symptoms on physical
examination,
x-rays, or in patient history
Persistently low ALP enzyme levels*
Signs and symptoms on physical examination,
x-rays, or in patient history
Persistently low ALP enzyme levels*
Check with your doctor for the appropriate age- and sex-adjusted reference range.
After all those years, I finally
received my diagnosis,
and I felt
vindicated and surprisingly happy.
I knew there was a
treatment, and I was excited to try it.”
Sheila, HPP STAR
Below are other diseases that may be more common
and have shared symptoms with HPP.
Diseases in bold often have overlapping symptoms
and therefore can be common misdiagnoses.
When it comes to rare diseases, specialists are important. Specialists are trained to treat rare diseases and may better understand ways to manage symptoms.
If you believe you or someone you care for has HPP but has not been diagnosed, look for a specialist who may be familiar with HPP. Some specialists who may be able to help include:
Study the role that genes play in disease and health
Study the bones, joints, ligaments, tendons, and muscles
Study hormone imbalances
Study pain and disorders of the joints, muscles, tendons, bones, and other connective tissues
Enroll in OneSource™ to get personalized patient support from Alexion at 1.888.765.4747.
Learn More about OneSource™
AT ONESOURCE, WE ARE BY YOUR SIDE THROUGHOUT YOUR JOURNEY, FROM LEARNING ABOUT YOUR CONDITION TO HELPING YOU ACCESS THE THERAPY YOU'VE BEEN PRESCRIBED. PATIENTS' NEEDS ARE OUR TOP PRIORITY.
–Deana,
ONESOURCE CASE MANAGER
What is the most important information I should know about STRENSIQ® (asfotase alfa)?
STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:
The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.
You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:
Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.
There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.
To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/
medwatch.
INDICATION
What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).
Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.
What is the most important information I should know about STRENSIQ® (asfotase alfa)?
STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:
The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.
You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:
Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.
There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.
To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/
medwatch.
INDICATION
What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).
Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.
