OUR STRENSIQ ROUTINE
Quinn and I have our STRENSIQ routine. He retrieves the vials while I prepare syringes and supplies. Depending upon the site, either he or I do the injection.”
Kara, Caregiver HPP STAR
KARA, CAREGIVER HPP STAR AND
QUINN, WHO
LIVES WITH HPP
live with confidence
STRENSIQ® (asfotase alfa) is an injection given under the skin (called a subcutaneous injection) and can be conveniently taken at home or wherever you go.
HOW STRENSIQ IS DOSED
STRENSIQ is dosed in milligrams based on weight. You and your doctor will decide which dosage and treatment schedule are right for you. As your weight changes, your dosage may also change depending on your doctor’s recommendations.
STRENSIQ is dosed as either:
It is important to use STRENSIQ as described in the Patient Prescribing Information and Instructions for Use, or as instructed by your doctor, nurse, and/or pharmacist.
Strensiq Injection
How-To
PREPARING FOR SELF-INJECTION
Some people with hypophosphatasia (HPP) may feel like the condition takes away their independence.
Self-injecting STRENSIQ can take back some of this lost independence. Controlling injections can be empowering for some people, but it can also seem like a scary step to take. To prepare for self-injections, consider the following ideas:
Ask questions
If your doctor decides you or someone you care for is ready to self-inject STRENSIQ, do not hesitate to ask questions. It is important to ensure everyone involved is comfortable making this transition.
Set a routine
Establishing a routine can help someone adapt to remembering their injections. For example, some may prefer to inject in the morning before eating breakfast, while others may wish to inject at night before going to bed.
Monitor at first
It may also be beneficial for a caregiver to monitor the first few self-injections. Having someone who is familiar with the injection process may relieve some anxiety about self-injecting.
Record important HPP information on a medical alert card. In the event of an emergency, this card can quickly communicate your condition and specific needs to medical personnel.
TIPS FOR SMOOTH INJECTION
Whether you are injecting STRENSIQ into yourself or someone you care for, it’s normal to feel anxious.
An important part of the process is for you to feel confident injecting STRENSIQ. If you need anything clarified about injection, don’t be afraid to ask questions or have your doctor review something more than once.
STRENSIQ can be injected under the skin of the stomach area, upper arms, upper legs, or buttocks.
STRENSIQ should not be injected into the buttocks for infants.
Choose a different area each time you inject to help avoid irritation at the injection site.
Do not inject STRENSIQ into skin that is red, hot, or swollen.
STRENSIQ may cause serious side effects, including serious allergic (hypersensitivity) reactions and skin thickening or pits at the injection site (lipodystrophy).
Recommended injection sites
Speak with your nurse, doctor, and/or pharmacist for more information on where to inject STRENSIQ.
RESOURCES FOR INJECTION-SITE REACTIONS (ISRs)
You may experience ISRs, which are painful, itchy, or swollen skin after injecting STRENSIQ® (asfotase alfa). A local skin injection-site reaction is one of the most common side effects of STRENSIQ.
ISRs may appear as:
- Red skin patches
- Bruising
- Color change
- Pain
- Itching
- Thinning
- Swelling
- Pits
- Bumps
- Hardening/thickening of the skin
STRENSIQ INJECTION RESOURCES
Injection starter kit
In your first shipment of STRENSIQ, you will receive an injection starter kit. This kit provides an injection supply mat, injection site tracker and calendar, and other tools that will help establish a routine with STRENSIQ.
Injection IQ
Read a complete guide on injecting STRENSIQ into yourself or someone you care for.
OneSource™ Case Managers are always available to talk through questions or concerns about injections. Reach out at 1.888.765.4747, OneSource@alexion.com, or AlexionOneSource.com.
FINDING INJECTION COURAGE
LOOKING FOR MORE STRENSIQ TIPS?
It’s normal to feel uneasy about fitting STRENSIQ into your routine. Check out more tips to help you feel confident as you begin and continue treatment.
What is the most important information I should know about STRENSIQ® (asfotase alfa)?
STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
- difficulty breathing
- choking sensation
- swelling of your eyes, lips, or tongue
- dizziness
- nausea or vomiting
- fever
- headache
- sweating
- feeling irritable
- chills
- skin redness
- skin rash or hives
-
itching or numbness of the
tongue, lips, cheeks, or gums
What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:
- skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
- calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
- immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.
The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.
You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:
- have had an allergic reaction to STRENSIQ.
- are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.
Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.
There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.
To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/
medwatch.
INDICATION
What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).
Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.
What is the most important information I should know about STRENSIQ® (asfotase alfa)?
STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:
- difficulty breathing
- choking sensation
- swelling of your eyes, lips, or tongue
- dizziness
- nausea or vomiting
- fever
- headache
- sweating
- feeling irritable
- chills
- skin redness
- skin rash or hives
-
itching or numbness of the
tongue, lips, cheeks, or gums
What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:
- skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
- calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
- immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.
The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.
You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:
- have had an allergic reaction to STRENSIQ.
- are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.
Tell your healthcare provider about all the
medicines you
take,
including
prescription and over-the-counter medicines,
vitamins, and herbal
supplements.
There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.
To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at
1-800-FDA-1088
or
www.fda.gov/
medwatch.
INDICATION
What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine
used to
treat people
with perinatal, infantile, and juvenile onset
hypophosphatasia (HPP).
Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.