
Juliana, Living with Hpp
STRENSIQ REPLACES
WHAT’S MISSING
As the only FDA-approved enzyme replacement therapy for people with perinatal/infantile-onset and juvenile-onset hypophosphatasia (HPP), STRENSIQ® (asfotase alfa) replaces alkaline phosphatase (ALP) and improves bone health.
ALP HELPS FORM HEALTHY BONES
ALP HELPS FORM HEALTHY BONES
Calcium and phosphate are two of the essential components needed to create and maintain healthy bones. ALP helps mineralize bone by freeing phosphate so it can combine with calcium and form the building blocks needed to make bones.
Bone mineralization is the process of minerals working together to develop bones. This involves many specific steps that need to be followed in order for bones to reach the right hardness, strength, and size.
STRENSIQ REPLACES ALP
Because people with HPP don’t have enough of the ALP enzyme, phosphate isn’t free to bind with calcium to form healthy, mineralized bones. As a result, people with HPP have soft or weak bones.
People born with HPP don’t have enough active ALP enzyme, which is needed to “mineralize” bones.
STRENSIQ replaces the ALP your body needs to build healthy bones.
STRENSIQ frees phosphate so it can combine with calcium to form the building blocks needed to make bone.
Calcium and phosphate work together to build healthier, stronger bones.

REPLACE WHAT’S MISSING
STRENSIQ HELPS FORM HEALTHY BONES
STRENSIQ can replace the ALP your body needs to free phosphate (PO4) and allow it to
bind together with calcium (Ca) to build healthy bones.
STRENSIQ treats people with perinatal/infantile-onset and juvenile-onset HPP, but it is important to note that every person is different. Responses to treatment may vary.
When symptoms manifest in utero and are apparent at birth it is perinatal-onset HPP. Someone who experiences symptoms before 6 months of age is living with infantile-onset HPP. Someone who experiences symptoms between the ages of 6 months and 18 years old is living with juvenile-onset HPP.

HPP PATIENT SUPPORT
Enroll in OneSource™ to get personalized patient support from Alexion at 1.888.765.4747.
Learn More about OneSource™

AT ONESOURCE, WE ARE BY YOUR SIDE THROUGHOUT YOUR JOURNEY, FROM LEARNING ABOUT YOUR CONDITION TO HELPING YOU ACCESS THE THERAPY YOU'VE BEEN PRESCRIBED. PATIENTS' NEEDS ARE OUR TOP PRIORITY.
–Deana,
ONESOURCE CASE MANAGER


STRENSIQ CAN HELP PEOPLE LIVING WITH HPP
See how STRENSIQ may improve bone health, mobility, and more.
STRENSIQ may cause serious side effects, including
- Serious allergic (hypersensitivity) reactions happened
in some people who
use
STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency
room right away if you
or
your loved one have any of the signs and symptoms of a serious allergic
reaction, including
- Difficulty breathing
- Swelling of your eyes, lips, or tongue
- Hives
- Feeling faint
- Nausea or vomiting
- Dizziness
- Itching of your lips, tongue, or throat
- Choking sensation
- Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.
- Calcium buildup in the eyes and kidneys can occur if you or your loved one have HPP. Your healthcare provider should check the eyes and kidneys while you or your loved one use STRENSIQ.
- Decreased efficacy. Contact your healthcare provider if you or your loved one notice STRENSIQ is no longer working or experience worsening symptoms of HPP (e.g., increased respiratory support, increased difficulty walking, new fractures).
The most common side effects of STRENSIQ include local skin injection-site reactions (red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys.
STRENSIQ may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed.
These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1‑800‑FDA‑1088.
INDICATION
What is STRENSIQ?
STRENSIQ is a prescription medicine used to treat people with
perinatal/infantile- and
juvenile-onset hypophosphatasia (HPP).
Please see STRENSIQ full Prescribing Information, including Patient Information and Instructions for Use.
STRENSIQ may cause serious side effects, including
- Serious allergic (hypersensitivity) reactions happened
in some people who
use
STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency
room right away if you
or
your loved one have any of the signs and symptoms of a serious allergic
reaction, including
- Difficulty breathing
- Swelling of your eyes, lips, or tongue
- Hives
- Feeling faint
- Nausea or vomiting
- Dizziness
- Itching of your lips, tongue, or throat
- Choking sensation
- Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.
- Calcium buildup in the eyes and kidneys can occur if you or your loved one have HPP. Your healthcare provider should check the eyes and kidneys while you or your loved one use STRENSIQ.
- Decreased efficacy. Contact your healthcare provider if you or your loved one notice STRENSIQ is no longer working or experience worsening symptoms of HPP (e.g., increased respiratory support, increased difficulty walking, new fractures).
The most common side effects of STRENSIQ include local skin injection-site reactions (red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys.
STRENSIQ may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed.
These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1‑800‑FDA‑1088.
INDICATION
What is STRENSIQ?
STRENSIQ is a prescription medicine used to treat people with
perinatal/infantile- and
juvenile-onset hypophosphatasia (HPP).