KARA, CAREGIVER HPP STAR AND
QUINN, WHO LIVES WITH HPP

STRENSIQ^® (asfotase alfa) is the first and only prescription medicine used to treat people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).

Hear about the journey forward from people being treated with STRENSIQ.

LET’S CONNECT

WHICH BEST
DESCRIBES YOU?

(CHECK ALL THAT APPLY)

I think I (or someone I care about) could have HPP, but I don’t know the next steps.

I am a person living with or caring for someone with HPP, wanting to learn more about treatment.

I am a person living with or caring for someone with HPP, currently receiving treatment with STRENSIQ.

Talk to someone either living with or caring for someone with HPP.

Listen to an HPP healthcare professional and a patient or caregiver talk about the condition.

Talk to someone either living with or caring for someone with HPP and treating with STRENSIQ.

Learn more about what I can expect with STRENSIQ.

Listen to an HPP healthcare professional and a patient or caregiver talk about STRENSIQ.

Learn more about starting or administering STRENSIQ.

Talk to someone either living with or caring for someone with HPP and treating with STRENSIQ.

Listen to an HPP healthcare professional and a patient or caregiver talk about STRENSIQ.

Learn more about what I can expect with STRENSIQ.

Receive guidance on administering STRENSIQ.

Want information about HPP?

We recommend THAT YOU…

Attend an HPP Educational Event

Register to attend an educational, no-cost HPP webinar and/or live event. You’ll hear from someone whose life has been impacted by HPP, as well as a healthcare provider specializing in HPP.

Sign up for our Peer Connects program to talk to someone
impacted by HPP

Peer Connects is a phone-based program that matches you with an HPP STAR who will share their story with you and can answer questions about HPP.

Connect with OneSource™

OneSource™ is a complimentary, personalized patient support program offered by Alexion. When you enroll in the program, you’ll work with a dedicated team of people with expertise in rare conditions and health insurance.

REQUEST A STARTER KIT

Coping with HP

Fill out the form below to connect with an HPP STAR.

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In connecting with OneSource™,
I got such great information.
They helped me with my
insurance, they helped me with
my questions. If they didn’t have
the answers, they helped me
find them. There’s always
wonderful people on the other
end of the line that make me
feel as though I’m not alone in
this.”

Sharon, HPP STAR

OPTION 2

WANT INFORMATION ABOUT STARTING TREATMENT WITH STRENSIQ?

We recommend THAT YOU…

CONNECT WITH ONESOURCE™

OneSource™ is a complimentary, personalized patient support
program offered by Alexion. When you enroll in the program, you’ll
work with a dedicated team of people with expertise in rare
conditions and health insurance.

Fill out the form below to get in touch with a OneSource™ team
member.

When we decided that Juliana
was going to take STRENSIQ,
and that we had to deliver it by
injection, I think I was
more nervous than Juliana was. We
were trained at the doctor’s
office, and I administered that
first injection and Juliana didn’t
bat an eyelash.”

Becky, Caregiver HPP STAR
and Juliana, who lives with
HPP

OPTION 4

WANT INFORMATION ABOUT STARTING TREATMENT WITH STRENSIQ?

We recommend THAT YOU…

REQUEST A STARTER KIT

Coping with HPP can be difficult but administering treatment shouldn’t
have to be. The STRENSIQ Patient Starter Kit is equipped with tools
to help familiarize you with STRENSIQ.

Fill out the form below to request a STRENSIQ Patient Starter Kit.

HPP Support

Explore support options, find helpful downloads,
and meet other people living with HPP.

HPP Resources

courage TO USE Strensiq

STRENSIQ is an injectable prescription medication
you can take at home as part of your routine.

HOW TO USE STRENSIQ

Life with strensiq

When I think about the journey that Quinn has been on and continues on, I see him finding his sense of independence—every day, every week, every year.”

Kara, Caregiver HPP STAR

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What is the most important information I should know about STRENSIQ® (asfotase alfa)?
STRENSIQ may cause serious side effects, including severe allergic (hypersensitivity) reactions. Allergic reactions are common with STRENSIQ treatment and can be severe and life-threatening. Severe allergic reactions have happened in some people within minutes after receiving STRENSIQ and more than 1 year after starting treatment with STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one get any of the following signs and symptoms of a serious allergic reaction:

difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the
tongue, lips, cheeks, or gums

What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

The most common side effects of STRENSIQ include local skin injection site reactions such as skin redness, bruising, color change, pain, itching, hardening of the skin (induration), swelling, and bumps. These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:

have had an allergic reaction to STRENSIQ.
are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

There is a registry for people who use STRENSIQ. The purpose of this registry is to collect information about HPP and about what happens when you use STRENSIQ for a long time. For more information about this registry, talk with your healthcare provider or go to www.hppregistry.com.

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at 1-800-FDA-1088 or www.fda.gov/
medwatch.

What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine used to treat people with perinatal, infantile, and juvenile onset hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.

difficulty breathing
choking sensation
swelling of your eyes, lips, or tongue
dizziness
nausea or vomiting
fever
headache
sweating
feeling irritable
chills
skin redness
skin rash or hives
itching or numbness of the
tongue, lips, cheeks, or gums

What are the other possible side effects of STRENSIQ?
STRENSIQ may cause other serious side effects, including:

skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy is common and has happened after several months in people treated with STRENSIQ.
calcium build-up in the eyes and kidneys. People with HPP are at increased risk for developing calcium build-up in the body. Calcium build-up in the eyes and kidneys has happened and is a common side effect of STRENSIQ. Calcium build-up in the eyes and kidneys may also happen in people with HPP who are not treated with STRENSIQ. Your healthcare provider should check your eyes and kidneys before and during treatment with STRENSIQ.
immune-related effects. You may develop antibodies during treatment that may decrease how well STRENSIQ works. Tell your healthcare provider right away if you get worsening symptoms of HPP including: difficulty breathing, difficulty walking, feeling tired, bone pain, stiff joints, or loss of appetite.

You will begin receiving STRENSIQ under the supervision of a healthcare provider. Tell your healthcare provider about all your medical conditions, including if
you:

have had an allergic reaction to STRENSIQ.
are pregnant or plan to become pregnant. It is not known if STRENSIQ will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if STRENSIQ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use STRENSIQ.

Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins, and herbal supplements.

To report SUSPECTED SIDE EFFECTS, contact Alexion
Pharmaceuticals, Inc. at
1-844-259-6783 or FDA at 1-800-FDA-1088 or www.fda.gov/
medwatch.

What is STRENSIQ?
STRENSIQ® (asfotase alfa) is a prescription medicine used to treat people with perinatal, infantile, and juvenile onset hypophosphatasia (HPP).

Please see the full Prescribing Information and Patient Information, including Boxed WARNING regarding severe allergic (hypersensitivity) reaction.

What is HPP?

Life with HPP

LET’S CONNECT

WHICH BEST DESCRIBES YOU?