Hypophosphatasia is an inherited, lifelong condition that impacts bones and bodies. Although the onset of hypophosphatasia can occur at any stage of life, the information contained here relates to two types: perinatal/infantile-onset hypophosphatasia and juvenile-onset hypophosphatasia. Perinatal/infantile-onset hypophosphatasia is defined as symptoms appearing at <6 months of age, while juvenile-onset hypophosphatasia is defined as symptoms appearing between 6 months and 18 years of age. People with hypophosphatasia have low levels of an enzyme called alkaline phosphatase that is naturally present in the body and necessary for bone creation and maintenance.
Low alkaline phosphatase
Under normal conditions, alkaline phosphatase (ALP) allows calcium and phosphate to bind together to form healthy, mineralized bones. But in hypophosphatasia, ALP is low, so less phosphate is available to bind with calcium and create strong bones. Therefore, in people with hypophosphatasia, bones can be soft or weak.
Hypophosphatasia can affect:
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Bones
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Breathing
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Growth
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Mobility and Gait
People with hypophosphatasia often have difficulty walking
Hypophosphatasia is a rare genetic disorder characterized by the abnormal development of bones and teeth. These abnormalities occur due to defective mineralization, the process by which bones and teeth take up minerals such as calcium and phosphorus which are needed for proper hardness and strength. Strensiq works by replacing the alkaline phosphataseenzyme so that phosphate and calcium can bind together and improve bone health.
Strensiq® can improve bone health in people with perinatal/infantile-onset and juvenile-onset hypophosphatasia
INDICATION & IMPORTANT SAFETY INFORMATION
INDICATION
What is STRENSIQ?
Strensiq is a prescription medicine used to treat people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).
IMPORTANT SAFETY INFORMATIONWhat are the possible side effects of STRENSIQ?
STRENSIQ may cause serious side effects, including
- Serious allergic (hypersensitivity) reactions happened in some people who use STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one have any of the signs and symptoms of a serious allergic reaction, including
- Difficulty breathing
- Swelling of your eyes, lips, or tongue
- Hives
- Feeling faint
- Nausea or vomiting
- Dizziness
- Itching of your lips, tongue, or throat
- Choking sensation
- Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.
- Calcium buildup in the eyes and kidneys can occur if you or your loved one have HPP. Your healthcare provider should check the eyes and kidneys while you or your loved one use STRENSIQ.
- Decreased efficacy. Contact your healthcare provider if you or your loved one notice STRENSIQ is no longer working or experience worsening symptoms of HPP (e.g., increased respiratory support, increased difficulty walking, new fractures).
Strensiq may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.
Tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.
These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1-800-FDA-1088.
Please see STRENSIQ full Prescribing Information, including Patient Information and Instructions for Use.