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How to inject Strensiq® (asfotase alfa)

How to inject Strensiq®

If you and your doctor decide Strensiq is right for you, your doctor will talk to you about injecting Strensiq.

It’s OK to ask questions or ask your doctor to review something more than once.

The most important thing is for you to feel confident injecting Strensiq.

Tips for injecting Strensiq®

Speak with your doctor, nurse, or pharmacist about the best areas to inject Strensiq for your child.

  • Carefully read the Patient Labeling and Instructions for Use
  • It can be injected under the skin of the hips, stomach, upper arms, or upper legs
  • Choose a different area each time you administer an injection to help avoid irritation and reactions at the injection site
  • Do not inject Strensiq into skin that is red, hot, or swollen
  • Always give the exact dose of Strensiq prescribed by your doctor. Before starting Strensiq, your doctor will speak with you about how often Strensiq should be injected

Step-by-step Strensiq® injection instructions.

Download our step-by-step injection instructions.

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Strensiq is a prescription medicine used to treat people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).

What are the possible side effects of STRENSIQ?
STRENSIQ may cause serious side effects, including
  • Serious allergic (hypersensitivity) reactions happened in some people who use STRENSIQ. Stop using STRENSIQ and go to the nearest hospital emergency room right away if you or your loved one have any of the signs and symptoms of a serious allergic reaction, including
    • Difficulty breathing
    • Swelling of your eyes, lips, or tongue
    • Hives
    • Feeling faint
    • Nausea or vomiting
    • Dizziness
    • Itching of your lips, tongue, or throat
    • Choking sensation
  • Skin thickening or pits at the injection site (lipodystrophy) has happened several months after using STRENSIQ.
  • Calcium buildup in the eyes and kidneys can occur if you or your loved one have HPP. Your healthcare provider should check the eyes and kidneys while you or your loved one use STRENSIQ.
  • Decreased efficacy. Contact your healthcare provider if you or your loved one notice STRENSIQ is no longer working or experience worsening symptoms of HPP (e.g., increased respiratory support, increased difficulty walking, new fractures).
The most common side effects of STRENSIQ include local skin injection-site reactions (including red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys.

Strensiq may affect other lab test results, therefore it is important that you present your Medical Alert Card to your healthcare team so they are aware that you are being treated with an alkaline phosphatase (ALP) replacement therapy which may cause incorrect results on certain laboratory tests.

 Tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

These are not all the possible side effects of STRENSIQ. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1-800-FDA-1088.

Please see STRENSIQ full Prescribing Information, including Patient Information and Instructions for Use.