Strensiq® (asfotase alfa) Dosing

How is Strensiq® given?

  • Strensiq is given as an injection under the skin (called a subcutaneous injection)
  • Depending on a person’s age and ability, Strensiq can be self-injected or injected by a caregiver
  • Always use Strensiq exactly as your healthcare provider tells you
  • Speak with your doctor about how much Strensiq to use and when to use it

How is Strensiq® dosed?

Strensiq is dosed in milligrams based on weight. Strensiq is available as either 1 mg per kg of body weight, 6 times per week, or 2 mg per kg of body weight, 3 times per week. Your doctor will decide which dosage is right for you.

If needed, the dose may be increased to 9 mg/kg, 3 times per week, for children with perinatal/infantile-onset hypophosphatasia.

If there have been any significant changes in weight for you or your child, your doctor will adjust the dosage.

It is important to use Strensiq as described in the Patient Prescribing Information and Instructions for Use , or as instructed by your doctor, nurse, or pharmacist.

Learn how to inject Strensiq® (asfotase alfa)

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Important Safety Information

What is Strensiq® (asfotase alfa)?

Strensiq is a prescription medicine used to treat people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).

What are the possible side effects of Strensiq?

Strensiq may cause serious side effects, including

  • Serious allergic (hypersensitivity) reactions. Serious allergic reactions have happened in some people who use Strensiq. Stop using Strensiq and go to the nearest hospital emergency room right away if you have any of the signs and symptoms of a serious allergic reaction, including
    • Difficulty breathing
    • Swelling of your eyes, lips, or tongue
    • Hives
    • Feeling faint
    • Nausea or vomiting
    • Dizziness
    • Itching of your lips, tongue, or throat
    • Choking sensation
  • Skin thickening or pits at the injection site (lipodystrophy). Lipodystrophy at the injection site has happened several months after using Strensiq
  • Calcium buildup in your eyes and kidneys. Your healthcare provider should check your eyes and kidneys while you use Strensiq
The most common side effects of Strensiq include local skin injection-site reactions (including red skin patches, bruising, color change, pain, itching, thinning, swelling, pits, and bumps) and calcium buildup in your eyes and kidneys. These are not all of the possible side effects of Strensiq. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to the US Food and Drug Administration at 1-800-FDA-1088.