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Learn more about Strensiq® (asfotase alfa) and HPP.

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Resources

Strensiq Prescribing Information
Strensiq Prescribing Information.
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View complete Strensiq® Patient Prescribing Information
View complete Strensiq® Patient Prescribing Information.
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Access personalized support for patients with rare diseases provided by dedicated case managers
Access personalized support for patients with rare diseases provided by dedicated case managers.
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Help your patients take the next step with Strensiq®
Help your patients take the next step with Strensiq®.
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View the Strensiq Self-Injection Guide
View the Strensiq Self-Injection Guide.
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View the Patient Caregiver Injection Guide
View the Patient/Caregiver Injection Guide
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Watch the Strensiq (asfotase alfa) U.S. product video
Watch the Strensiq (asfotase alfa) U.S. product video.
See how Strensiq improved mobility and gait in patients with juvenile-onset hypophosphatasia
See how Strensiq improved mobility and gait in patients with juvenile-onset hypophosphatasia.
Watch to learn about Aubrey, her diagnosis with hypophosphatasia, and her experience with Strensiq
Watch to learn about Aubrey, her diagnosis with hypophosphatasia, and her experience with Strensiq.
Meet Adelyn’s parents as they talk about her diagnosis with hypophosphatasia and her experience in a clinical trial with Strensiq.
Meet Adelyn’s parents as they talk about her diagnosis with hypophosphatasia and her experience in a clinical trial with Strensiq.
View chest radiograph of patient with perinatal/infantile-onset hypophosphatasia aged 2.9 weeks at baseline.
View chest radiograph of patient with perinatal/infantile-onset hypophosphatasia showing substantial healing after 24 weeks of treatment with Strensiq.
View knee radiograph of patient with perinatal/infantile-onset hypophosphatasia aged 6 months at baseline.
View knee radiograph of patient with perinatal/infantile-onset hypophosphatasia showing substantial healing after 24 weeks of treatment with Strensiq.

Indication

STRENSIQ® is indicated for the treatment of patients with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP)

Important Safety Information

  • Hypersensitivity reactions, including anaphylaxis, have been reported in STRENSIQ-treated patients. Signs and symptoms consistent with anaphylaxis included difficulty breathing, choking sensation, nausea, periorbital edema, and dizziness. These reactions have occurred within minutes after subcutaneous administration of STRENSIQ and can occur in patients on treatment for more than one year. Other hypersensitivity reactions have also been reported in STRENSIQ-treated patients, including vomiting, fever, headache, flushing, irritability, chills, skin erythema, rash, pruritus and oral hypoesthesia. If a severe hypersensitivity reaction occurs, discontinue STRENSIQ treatment and initiate appropriate medical treatment. Consider the risks and benefits of re-administering STRENSIQ to individual patients following a severe reaction. If the decision is made to re-administer the product, monitor patients for a reoccurrence of signs and symptoms of a severe hypersensitivity reaction.
  • Localized lipodystrophy, including lipoatrophy and lipohypertrophy, has been reported at injection sites after several months in patients treated with STRENSIQ. Advise patients to follow proper injection technique and to rotate injection sites.
  • Patients with HPP are at increased risk for developing ectopic calcifications. In clinical trials, 14 cases (14%) of ectopic calcification of the eye including the cornea and conjunctiva, and the kidneys (nephrocalcinosis) were reported. There was insufficient information to determine whether or not the reported events were consistent with the disease or due to STRENSIQ. No visual changes or changes in renal function were reported. Ophthalmology examinations and renal ultrasounds are recommended at baseline and periodically during treatment with STRENSIQ to monitor for signs and symptoms of ophthalmic and renal ectopic calcifications and for changes in vision or renal function.
  • The most common adverse reactions (≥ 10%) are injection site reactions, lipodystrophy, ectopic calcifications and hypersensitivity reactions.
                                                                                       

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